Somerset Wendy, Stout Steven C, Miller Andrew H, Musselman Dominique
Emory University, School of Medicine, Atlanta, Georgia 30322, USA.
Oncology (Williston Park). 2004 Jul;18(8):1021-34; discussion 1035-6, 1047-8.
Major depression and depressive symptoms, although commonly encountered in patients with medical illnesses, are frequently underdiagnosed and undertreated in women with breast cancer. Depression and its associated symptoms diminish quality of life, adversely affect compliance with medical therapies, and reduce survival. Treatment of depression in women with breast cancer improves their dysphoria and other depressive symptoms, enhances quality of life, and may increase longevity. In this review, studies that investigate pathophysiologic alterations in patients with cancer and comorbid depression are discussed, and the few studies on treatment of depression and related symptoms in women with breast cancer are examined.
重度抑郁症及抑郁症状虽然在患有内科疾病的患者中很常见，但在乳腺癌女性患者中常常未得到充分诊断和治疗。抑郁症及其相关症状会降低生活质量，对医疗治疗的依从性产生不利影响，并缩短生存期。对乳腺癌女性患者的抑郁症进行治疗可改善她们的烦躁不安及其他抑郁症状，提高生活质量，并可能延长寿命。在这篇综述中，我们将讨论调查癌症合并抑郁症患者病理生理改变的研究，并审视关于治疗乳腺癌女性患者抑郁症及相关症状的少数研究。
