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尼可地尔:对其用于稳定型心绞痛管理(包括高危患者)的综述。

Nicorandil: a review of its use in the management of stable angina pectoris, including high-risk patients.

作者信息

Simpson Dene, Wellington Keri

机构信息

Adis International Limited, Auckland, New Zealand.

出版信息

Drugs. 2004;64(17):1941-55. doi: 10.2165/00003495-200464170-00012.

DOI:10.2165/00003495-200464170-00012
PMID:15329045
Abstract

Nicorandil (Adancor, Angicor, Dancor, Nikoril [Europe], Ikorel [Europe and Oceania], Sigmart [Japan, Korea and Taiwan]) is an adenosine triphosphate (ATP)-sensitive potassium (KATP) channel agonist with nitrate-like properties used in the management of stable angina pectoris. With well established monotherapeutic antianginal activity and a beneficial effect (when added to optimal antianginal therapy) on clinical outcomes in high-risk patients with stable angina, twice-daily oral nicorandil is a useful alternative or addition to other antianginal therapy.

摘要

尼可地尔(Adancor、Angicor、Dancor、Nikoril[欧洲]、Ikorel[欧洲和大洋洲]、Sigmart[日本、韩国和台湾])是一种具有硝酸盐样特性的三磷酸腺苷(ATP)敏感性钾(KATP)通道激动剂,用于治疗稳定型心绞痛。尼可地尔每日口服两次,具有明确的单一抗心绞痛活性,且(添加至最佳抗心绞痛治疗方案时)对稳定型心绞痛高危患者的临床结局有有益影响,是其他抗心绞痛治疗的有用替代药物或补充药物。

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Cardiovasc Drugs Ther. 2004 Jan;18(1):37-46. doi: 10.1023/B:CARD.0000025754.08942.03.
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Safety profile of nicorandil--prescription-event monitoring (PEM) study.
Pharmacoepidemiol Drug Saf. 1999 May;8(3):197-205. doi: 10.1002/(SICI)1099-1557(199905/06)8:3<197::AID-PDS422>3.0.CO;2-T.
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Preconditioning protects by inhibiting the mitochondrial permeability transition.预处理通过抑制线粒体通透性转换发挥保护作用。
使用负载尼可地尔的纳米级载体SiO@PEG改善急性心肌缺血大鼠的冠状动脉微循环。
Drug Deliv Transl Res. 2025 Mar 7. doi: 10.1007/s13346-025-01820-0.
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