Kwan Patrick, Brodie Martin J
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Epilepsia. 2004 Sep;45(9):1141-9. doi: 10.1111/j.0013-9580.2004.12704.x.
Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries. Meta-analyses of randomized controlled trials suggest that few differences in efficacy exist between PB and other established AEDs, but its possible deleterious cognitive and behavioral side effects remain a concern in the developed world. In contrast, high degrees of efficacy and tolerability in everyday clinical use have been demonstrated consistently in observational studies in developing countries. We propose that a pragmatic, comprehensive outcomes program be carried out, perhaps under the aegis of the Global Campaign Against Epilepsy, to optimize the conditions of the use of PB, so that more people around the world can benefit from this cost-effective medication and live more fulfilling lives.
苯巴比妥（PB）是发展中国家使用最广泛的抗癫痫药物（AED），在许多工业化国家也仍然是一种受欢迎的选择。随机对照试验的荟萃分析表明，PB与其他已确立的AED在疗效上几乎没有差异，但其可能存在的有害认知和行为副作用在发达国家仍是一个令人担忧的问题。相比之下，发展中国家的观察性研究一致表明，PB在日常临床使用中具有高度的疗效和耐受性。我们建议，或许在全球抗癫痫运动的支持下，开展一个务实、全面的结果项目，以优化PB的使用条件，使世界上更多的人能够从这种具有成本效益的药物中受益，并过上更充实的生活。
