Yavuz Handan, Say Ridvan, Andaç Müge, Bayraktar Necmi, Denizli Adil
Department of Chemistry, Biochemistry Division, Hacettepe University, Ankara, Turkey.
Biomagn Res Technol. 2004 Aug 26;2(1):5. doi: 10.1186/1477-044X-2-5.
Aluminum has recently been recognized as a causative agent in dialysis encephalopathy, osteodystrophy, and microcytic anemia occurring in patients with chronic renal failure who undergo long-term hemodialysis. Only a small amount of Al(III) in dialysis solutions may give rise to these disorders. METHODS: Magnetic poly(2-hydroxyethyl methacrylate) (mPHEMA) beads in the size range of 80-120 microm were produced by free radical co-polymerization of HEMA and ethylene dimethacrylate (EDMA) in the presence of magnetite particles (Fe3O4). Then, metal complexing ligand alizarin yellow was covalently attached onto mPHEMA beads. Alizarin yellow loading was 208 micromol/g. These beads were used for the removal of Al(III) ions from tap and dialysis water in a magnetically stabilized fluidized bed. RESULTS: Al(III) adsorption capacity of the beads decreased with an increase in the flow-rate. The maximum Al(III) adsorption was observed at pH 5.0. Comparison of batch and magnetically stabilized fluidized bed (MSFB) maximum capacities determined using Langmuir isotherms showed that dynamic capacity (17.5 mg/g) was somewhat higher than the batch capacity (11.8 mg/g). The dissociation constants for Al(III) were determined using the Langmuir isotherm equation to be 27.3 mM (MSFB) and 6.7 mM (batch system), indicating medium affinity, which was typical for pseudospecific affinity ligands. Al(III) ions could be repeatedly adsorbed and desorbed with these beads without noticeable loss in their Al(III) adsorption capacity. CONCLUSIONS: Adsorption of Al(III) demonstrate the affinity of magnetic dye-affinity beads. The MSFB experiments allowed us to conclude that this inexpensive sorbent system may be an important alternative to the existing adsorbents in the removal of aluminium.
铝最近被认为是在接受长期血液透析的慢性肾衰竭患者中发生的透析性脑病、骨营养不良和小细胞性贫血的致病因素。透析液中仅少量的Al(III)就可能引发这些病症。方法：通过在磁铁矿颗粒（Fe3O4）存在下使甲基丙烯酸2-羟乙酯（HEMA）和二甲基丙烯酸乙二酯（EDMA）进行自由基共聚，制备出尺寸范围为80 - 120微米的磁性聚甲基丙烯酸2-羟乙酯（mPHEMA）珠粒。然后，将金属络合配体茜素黄共价连接到mPHEMA珠粒上。茜素黄负载量为208微摩尔/克。这些珠粒用于在磁稳定流化床中从自来水和透析水中去除Al(III)离子。结果：珠粒对Al(III)的吸附容量随流速增加而降低。在pH 5.0时观察到最大Al(III)吸附量。使用朗缪尔等温线确定的分批和磁稳定流化床（MSFB）最大容量的比较表明，动态容量（17.5毫克/克）略高于分批容量（11.8毫克/克）。使用朗缪尔等温线方程确定Al(III)的解离常数为27.3毫摩尔（MSFB）和6.7毫摩尔（分批系统），表明具有中等亲和力，这是假特异性亲和配体的典型特征。Al(III)离子可以用这些珠粒反复吸附和解吸，而其Al(III)吸附容量没有明显损失。结论：Al(III)的吸附证明了磁性染料亲和珠粒的亲和力。MSFB实验使我们得出结论，这种廉价的吸附剂系统可能是现有吸附剂在去除铝方面的重要替代品。
