Suzuki Masatoshi, Lee Hwi-Cheul, Chiba Shuichi, Yonezawa Tomohiro, Nishihara Masugi
Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Japan.
J Reprod Dev. 2004 Aug;50(4):455-61. doi: 10.1262/jrd.50.455.
Methoxychlor (MXC) is a non-steroidal pesticide that is known to possess estrogenic activity, and therefore may be potentially hazardous to the development and/or reproduction. The present study assessed the effects of perinatal exposure to MXC on reproductive function after maturation in both male and female rats. Pregnant rats were fed a phytoestrogen-free diet containing different doses of MXC (24, 240, and 1200 ppm) from day 15 of gestation to day 10 after parturition, and reproductive functions of offspring were examined after maturation. In males, MXC exposure during the perinatal period decreased serum LH and FSH, but not testosterone levels, but it did not affect copulatory behavior. In females, MXC exposure prolonged the days exhibiting cornified vaginal smears during the estrous cycle. In addition, both the lordosis reflex and preovulatory LH surge on the presumptive proestrous evening were suppressed in MXC-exposed females. These results suggest that perinatal exposure to MXC exerts permanent effects on several aspects of the reproductive function in both male and female rats.
甲氧滴滴涕（MXC）是一种非甾体类农药，已知具有雌激素活性，因此可能对发育和/或生殖有潜在危害。本研究评估了围产期暴露于MXC对雄性和雌性大鼠成熟后生殖功能的影响。从妊娠第15天到产后第10天，给怀孕大鼠喂食含不同剂量MXC（24、240和1200 ppm）的无植物雌激素饮食，并在后代成熟后检查其生殖功能。在雄性大鼠中，围产期暴露于MXC会降低血清促黄体生成素（LH）和促卵泡生成素（FSH）水平，但不会影响睾酮水平，且对交配行为没有影响。在雌性大鼠中，MXC暴露会延长发情周期中出现角化阴道涂片的天数。此外，在假定的发情前期晚上，MXC暴露的雌性大鼠的脊柱前凸反射和排卵前LH激增均受到抑制。这些结果表明，围产期暴露于MXC会对雄性和雌性大鼠生殖功能的多个方面产生永久性影响。
