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内分泌干扰物会影响HOX基因表达的发育编程。

Endocrine disruptors affect developmental programming of HOX gene expression.

作者信息

Taylor Hugh S

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

出版信息

Fertil Steril. 2008 Feb;89(2 Suppl):e57-8. doi: 10.1016/j.fertnstert.2007.12.030.

DOI:10.1016/j.fertnstert.2007.12.030
PMID:18308065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2495774/
Abstract

HOX gene expression determines the differential developmental identity of the Müllerian duct. Diethylstilbestrol and several environmental xenoestrogens disrupt the development of the female reproductive tract by altering HOX gene expression, leading to structural and functional defects.

摘要

HOX基因表达决定了苗勒管的不同发育特征。己烯雌酚和几种环境中的外源性雌激素通过改变HOX基因表达来干扰女性生殖道的发育，从而导致结构和功能缺陷。

相似文献

1
Endocrine disruptors affect developmental programming of HOX gene expression.内分泌干扰物会影响HOX基因表达的发育编程。
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2
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system.子宫内己烯雌酚（DES）暴露会改变发育中的苗勒氏系统中Hox基因的表达。
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引用本文的文献

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Recent advances in the molecular mechanisms of Mayer-Rokitansky-Küster-Hauser syndrome.迈耶-罗基坦斯基-库斯特-豪泽综合征分子机制的最新进展
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本文引用的文献

1
Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development.接触外源性雌激素会影响正常子宫发育所需基因（Hoxa10）的表达。
FASEB J. 2007 Jan;21(1):239-46. doi: 10.1096/fj.06-6635com. Epub 2006 Nov 8.
2
Endocrine regulation of HOX genes.HOX基因的内分泌调节
Endocr Rev. 2006 Jun;27(4):331-55. doi: 10.1210/er.2005-0018. Epub 2006 Apr 21.
3
Exposure to bisphenol A is associated with recurrent miscarriage.接触双酚A与复发性流产有关。
Hum Reprod. 2005 Aug;20(8):2325-9. doi: 10.1093/humrep/deh888. Epub 2005 Jun 9.
4
Methoxychlor disrupts uterine Hoxa10 gene expression.甲氧滴滴涕会干扰子宫中Hoxa10基因的表达。
Endocrinology. 2005 Aug;146(8):3445-51. doi: 10.1210/en.2005-0341. Epub 2005 May 12.
5
Molecular regulation of mullerian development by Hox genes.Hox基因对苗勒氏管发育的分子调控
Ann N Y Acad Sci. 2004 Dec;1034:152-65. doi: 10.1196/annals.1335.018.
6
Long-term effects of fetal exposure to low doses of the xenoestrogen bisphenol-A in the female mouse genital tract.胎儿暴露于低剂量外源性雌激素双酚A对雌性小鼠生殖道的长期影响。
Biol Reprod. 2005 Jun;72(6):1344-51. doi: 10.1095/biolreprod.104.036301. Epub 2005 Feb 2.
7
Effects of methoxychlor exposure during perinatal period on reproductive function after maturation in rats.围产期暴露于甲氧滴滴涕对大鼠成熟后生殖功能的影响。
J Reprod Dev. 2004 Aug;50(4):455-61. doi: 10.1262/jrd.50.455.
8
Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10.HOXA10对哺乳动物生殖过程中着床周围EMX2表达的转录抑制作用。
Mol Cell Biol. 2003 Jan;23(1):1-13. doi: 10.1128/MCB.23.1.1-13.2003.
9
Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells.HOXA10对子宫内膜细胞中β3整合素亚基基因表达的直接调控。
Mol Endocrinol. 2002 Mar;16(3):571-9. doi: 10.1210/mend.16.3.0792.
10
In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing müllerian system.子宫内己烯雌酚（DES）暴露会改变发育中的苗勒氏系统中Hox基因的表达。
FASEB J. 2000 Jun;14(9):1101-8. doi: 10.1096/fasebj.14.9.1101.