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[血管生物材料:从生物医学工程到组织工程]

[Vascular biomaterials: from biomedical engineering to tissue engineering].

作者信息

Meddahi-Pellé Anne, Bataille Isabelle, Subra Pascale, Letourneur Didier

机构信息

Inserm U.460, CHU Xavier Bichat-Claude Bernard, Bâtiment Inserm 13, 46, rue Henri-Huchard, 75877 Paris Cedex 18, France.

出版信息

Med Sci (Paris). 2004 Jun-Jul;20(6-7):679-84. doi: 10.1051/medsci/2004206-7679.

Abstract

Biomaterials are already widely used in medical sciences. The field of biomaterials began to shift to produce materials able to stimulate specific cellular responses at the molecular level. The combined efforts of cell biologists, engineers, materials scientists, mathematicians, geneticists, and clinicians are now used in tissue engineering to restore, maintain, or improve tissue functions or organs. This rapidly expanding approach combines the fields of material sciences and cell biology for the molecular design of polymeric scaffolds with appropriate 3D configuration and biological responses. Future developments for new blood vessels will require improvements in technology of materials and biotechnology together with the increased knowledge of the interactions between materials, blood, and living tissues. Biomaterials represent a crucial mainstay for all these studies.

摘要

生物材料已在医学科学中广泛应用。生物材料领域已开始转向生产能够在分子水平上刺激特定细胞反应的材料。细胞生物学家、工程师、材料科学家、数学家、遗传学家和临床医生的共同努力现在被用于组织工程,以恢复、维持或改善组织功能或器官。这种迅速发展的方法将材料科学和细胞生物学领域结合起来,用于分子设计具有适当三维结构和生物反应的聚合物支架。新血管的未来发展将需要材料技术和生物技术的改进,以及对材料、血液和活组织之间相互作用的更多了解。生物材料是所有这些研究的关键支柱。

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