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[血吸虫性脊髓神经根病]

[Schistosomal myeloradiculopathy].

作者信息

Silva Luciana Cristina dos Santos, Maciel Pedro Ernane, Ribas João Gabriel Ramos, Pereira Sílvio Roberto de Sousa, Serufo José Carlos, Andrade Luciene Mota, Antunes Carlos Maurício, Lambertucci José Roberto

机构信息

Serviço de Doenças Infecciosas e Parasitárias da Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

出版信息

Rev Soc Bras Med Trop. 2004 May-Jun;37(3):261-72. doi: 10.1590/s0037-86822004000300013.

Abstract

Schistosomal myeloradiculopathy is the most severe and disabling ectopic form of schistosomiasis mansoni. Its prevalence in endemic areas has been underestimated. The diagnosis relies on the presence of low thoracic/upper lumbar neurological symptoms, demonstration of the Schistosoma mansoni infection by microscopic or serologic techniques, and exclusion of other causes of transverse myelitis. When treatment with antischistosomal drugs and corticosteroids is started early, the clinical response is surprisingly good and those left untreated do not improve and frequently die. There is no consensus about doses and duration of treatment, but a recent study suggests that when steroids are given for at least 6 months clinical improvement is enhanced. As the diagnosis of SMR is presumptive and treatment is essentially clinical, physicians should be aware of the disease and more research is needed to increase the accuracy of the diagnostic methods and, hence, to avoid routine laminectomy. With the advent of magnetic resonance imaging of the spinal cord the diagnosis of this ectopic form of the disease was facilitated. In accordance, the number of cases of schistosomal myelopathy reported is increasing rapidly.

摘要

血吸虫性脊髓神经根病是曼氏血吸虫病最严重且致残的异位形式。其在流行地区的患病率一直被低估。诊断依赖于存在胸段下部/腰段上部神经症状、通过显微镜或血清学技术证实曼氏血吸虫感染以及排除横贯性脊髓炎的其他病因。早期开始使用抗血吸虫药物和皮质类固醇治疗时,临床反应出奇地好,而未接受治疗的患者病情不会改善且常死亡。关于治疗剂量和疗程尚无共识,但最近一项研究表明,给予类固醇至少6个月可增强临床改善效果。由于血吸虫性脊髓神经根病的诊断是推测性的且治疗本质上是临床性的,医生应了解这种疾病,并且需要更多研究来提高诊断方法的准确性,从而避免常规椎板切除术。随着脊髓磁共振成像的出现,这种疾病的异位形式的诊断变得更加容易。相应地,报告的血吸虫性脊髓病病例数量正在迅速增加。

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