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Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.

作者信息

Kasai Y, Nambu J R, Lieberman P M, Crews S T

机构信息

Department of Biology, University of California, Los Angeles 90024.

出版信息

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3414-8. doi: 10.1073/pnas.89.8.3414.

DOI:10.1073/pnas.89.8.3414
PMID:1533042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC48878/
Abstract

The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/538e9b4cbe6e/pnas01082-0263-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/b2a44ba57881/pnas01082-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/016f34596572/pnas01082-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/538e9b4cbe6e/pnas01082-0263-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/b2a44ba57881/pnas01082-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/016f34596572/pnas01082-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/48878/538e9b4cbe6e/pnas01082-0263-a.jpg

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1
Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3414-8. doi: 10.1073/pnas.89.8.3414.
2
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本文引用的文献

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Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis.通过聚丙烯酰胺凝胶电泳研究乳糖阻遏物-操纵基因相互作用的平衡与动力学
Nucleic Acids Res. 1981 Dec 11;9(23):6505-25. doi: 10.1093/nar/9.23.6505.
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Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes.从十二烷基硫酸钠 - 聚丙烯酰胺凝胶中洗脱蛋白质、去除十二烷基硫酸钠以及酶活性的复性：大肠杆菌RNA聚合酶σ亚基、小麦胚芽DNA拓扑异构酶及其他酶的实验结果
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Su(H)-mediated repression positions gene boundaries along the dorsal-ventral axis of Drosophila embryos.Su(H) 介导的抑制作用将基因边界定位于果蝇胚胎的背腹轴上。
Dev Cell. 2014 Oct 13;31(1):100-13. doi: 10.1016/j.devcel.2014.08.005.
5
A conserved role for Snail as a potentiator of active transcription.Snail 作为转录激活增强子的保守作用。
Genes Dev. 2014 Jan 15;28(2):167-81. doi: 10.1101/gad.230953.113. Epub 2014 Jan 8.
6
Analysis of snail genes in the crustacean Parhyale hawaiensis: insight into snail gene family evolution.分析甲壳动物 Parhyale hawaiensis 中的蜗牛基因：深入了解蜗牛基因家族的进化。
Dev Genes Evol. 2012 May;222(3):139-51. doi: 10.1007/s00427-012-0396-6. Epub 2012 Mar 31.
7
Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS.主脑突变在果蝇中枢神经系统中产生独特的中线细胞群。
PLoS One. 2011;6(10):e26197. doi: 10.1371/journal.pone.0026197. Epub 2011 Oct 27.
8
The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo.蜗牛阻抑物抑制果蝇胚胎中暂停的 Pol II 的释放，而非延伸。
Curr Biol. 2011 Sep 27;21(18):1571-7. doi: 10.1016/j.cub.2011.08.019. Epub 2011 Sep 14.
9
Complex interactions between cis-regulatory modules in native conformation are critical for Drosophila snail expression.天然构象中的顺式调控模块之间的复杂相互作用对于果蝇 snail 表达至关重要。
Development. 2011 Sep;138(18):4075-84. doi: 10.1242/dev.069146. Epub 2011 Aug 3.
10
A prominent requirement for single-minded and the ventral midline in patterning the dorsoventral axis of the crustacean Parhyale hawaiensis.在构建夏威夷扁虾背腹轴模式时，对“一心”和腹中线有一个突出的要求。
Development. 2010 Oct;137(20):3469-76. doi: 10.1242/dev.055160. Epub 2010 Sep 15.
The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers.
果蝇发育基因“蜗牛”编码一种带有核酸结合指状结构域的蛋白质。
Nature. 1987;330(6146):395-8. doi: 10.1038/330395a0.
4
Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos.果蝇早期胚胎内胚层中twist基因序列及其蛋白质的核定位
EMBO J. 1988 Jul;7(7):2175-83. doi: 10.1002/j.1460-2075.1988.tb03056.x.
5
The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product.
Cell. 1988 Jan 15;52(1):143-51. doi: 10.1016/0092-8674(88)90538-7.
6
Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system.单-minded基因座的分子遗传学：一个参与果蝇神经系统发育的基因。
Cell. 1988 Jan 15;52(1):133-41. doi: 10.1016/0092-8674(88)90537-5.
7
The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA.使用硫代磷酸酯修饰的DNA快速高频产生寡核苷酸定向突变。
Nucleic Acids Res. 1985 Dec 20;13(24):8765-85. doi: 10.1093/nar/13.24.8765.
8
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo.背侧蛋白的核定位梯度决定了果蝇胚胎的背腹模式。
Cell. 1989 Dec 22;59(6):1189-202. doi: 10.1016/0092-8674(89)90774-5.
9
Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function.背侧蛋白从细胞质重新定位到细胞核与其功能相关。
Cell. 1989 Dec 22;59(6):1179-88. doi: 10.1016/0092-8674(89)90773-3.
10
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.果蝇中背侧形态发生素的梯度分布是由选择性核转运启动的。
Cell. 1989 Dec 22;59(6):1165-77. doi: 10.1016/0092-8674(89)90772-1.