Hilmi F A, Al-Allawi N A, Rassam M, Al-Shamma G, Al-Hashimi A
Department of Pathology, College of Medicine, University of Baghdad, Baghdad, Iraq.
East Mediterr Health J. 2002 Jan;8(1):42-8.
We attempted to characterize biochemically glucose-6-phosphate dehydrogenase (G6PD) variants in Iraqi individuals. Thus 758 healthy Iraqi males aged 18-60 years were randomly selected and 46 (6.1%) were G6PD deficient. Although the predominant non-deficient G6PD phenotype was G6PD B (92.6%), G6PD A+ was found in polymorphic frequency (1.3%). In the deficient group, 31 cases were fully characterized, including 17 cases with features consistent with G6PD Mediterranean variant, while 12 had other biochemical features and were labelled as non-Mediterranean variant. The remaining two deficient cases were characterized as G6PD A- variant. The presence of a significant number of non-Mediterranean variant was unexpected and may be related to the more heterogeneous background of the Iraqi people.
我们试图从生物化学角度对伊拉克个体中的葡萄糖-6-磷酸脱氢酶（G6PD）变体进行特征描述。因此，随机选取了758名年龄在18至60岁之间的健康伊拉克男性，其中46人（6.1%）存在G6PD缺乏症。虽然主要的非缺乏G6PD表型是G6PD B（92.6%），但发现G6PD A+以多态频率存在（1.3%）。在缺乏症组中，对31例进行了全面特征描述，其中17例具有与G6PD地中海变体一致的特征，而12例具有其他生化特征，被标记为非地中海变体。其余两例缺乏症病例被鉴定为G6PD A-变体。大量非地中海变体的存在出乎意料，可能与伊拉克人群更为多样化的背景有关。
