Alangari Abdulaziz S, El-Metwally Ashraf A, Alanazi Abdullah, Al Khateeb Badr F, Al Kadri Hanan M, Alshdoukhi Ibtehaj F, Aldubikhi Aljohrah I, Alruwaili Muzun, Alshahrani Awad
College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11426, Saudi Arabia.
King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
J Clin Med. 2023 Oct 20;12(20):6648. doi: 10.3390/jcm12206648.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common metabolic disorder affecting more than 400 million individuals worldwide. Being an X-linked disorder, the disease is more common among males than females. Various Arab countries estimated the prevalence of G6PD deficiency; however, findings from different countries have not been synthesized collectively. Hence, a systematic review was undertaken to synthesize the findings on the epidemiology of G6PD deficiency in all Arab countries. We performed an electronic systematic literature search based on the eligibility criteria using databases, including MEDLINE, Embase, and CINHAL. The studies included in the review were primary and original research studies assessing the prevalence or incidence, risk factors, or determinants of G6PD deficiency, and published in the English language in a peer-reviewed scientific journal between 2000 and 2022. The systematic review was carried out with the help of an updated PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. After the screening, 23 full texts were finalized for data extraction. The prevalence of G6PD deficiency ranged from 2 to 31% with a greater burden among high-risk populations like neonates with sickle cell anemia. The determinants included males, family history, consanguineous marriages, and geographic regions, which were all risk factors, except for body weight, which was a protective factor. The prevalence of G6PD deficiency varies across Arab countries, with a higher prevalence in males than females. Different regions of Arab countries need to revisit their screening and diagnostic guidelines to detect G6PD deficiency promptly and prevent unnecessary morbidity and mortality among their communities.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症是一种常见的代谢紊乱疾病，全球有超过4亿人受其影响。作为一种X连锁疾病，该疾病在男性中比女性更为常见。各个阿拉伯国家都对G6PD缺乏症的患病率进行了估计；然而，不同国家的研究结果尚未进行综合汇总。因此，开展了一项系统综述，以综合所有阿拉伯国家G6PD缺乏症流行病学的研究结果。我们根据纳入标准，利用包括MEDLINE、Embase和CINHAL在内的数据库进行了电子系统文献检索。纳入综述的研究为评估G6PD缺乏症患病率或发病率、风险因素或决定因素的原发性和原创性研究，且于2000年至2022年期间以英文发表在同行评审的科学期刊上。该系统综述借助更新后的PRISMA（系统综述和Meta分析的首选报告项目）清单进行。筛选后，最终确定了23篇全文用于数据提取。G6PD缺乏症的患病率在2%至31%之间，在镰状细胞贫血新生儿等高风险人群中负担更重。决定因素包括男性、家族史、近亲婚姻和地理区域，这些均为风险因素，体重除外，体重是一个保护因素。G6PD缺乏症的患病率在阿拉伯国家各不相同，男性患病率高于女性。阿拉伯国家的不同地区需要重新审视其筛查和诊断指南，以便及时发现G6PD缺乏症，并预防其社区内不必要的发病和死亡。
