Ryu Eui-Hyun, Zhao Yan
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
Org Lett. 2004 Sep 2;6(18):3187-9. doi: 10.1021/ol048679p.
[structure: see text] When four facially amphiphilic cholate derivatives are attached to a tetraaminocalixarene scaffold, the resulting molecule responds to environmental changes by rotation of the cholate units. In polar solvents, the molecule adopts a micellelike conformation with the hydrophilic alpha-faces of the cholates pointing outward. In nonpolar solvents, it turns inside out, assuming a reversed micellelike conformation with the hydrophobic beta-faces pointing outward. Switching between the two conformations is driven by solvophobic interactions and is fully reversible.
[结构：见正文] 当四个具有表面两亲性的胆酸盐衍生物连接到四氨基杯芳烃支架上时，所得分子通过胆酸盐单元的旋转对环境变化作出响应。在极性溶剂中，该分子呈现出胶束状构象，胆酸盐的亲水性α面指向外部。在非极性溶剂中，它会内外翻转，呈现出反向胶束状构象，疏水性β面指向外部。两种构象之间的转换由疏溶剂相互作用驱动，并且是完全可逆的。
