Peng Lingling, Mo Fanyang, Zhang Qinghai
Department of Integrative Structural and Computational Biology, The Scripps Research Institute , La Jolla, California 92037, United States.
J Org Chem. 2015 Jan 16;80(2):1221-8. doi: 10.1021/jo5023734. Epub 2015 Jan 6.
We describe cholate-based cage amphiphiles with a unique architecture that combines elements of structural rigidity and flexibility. The cage compounds are built by extending and bridging three polar chains underneath the concave steroid rings of cholate and capping with another rigid, symmetrically trifunctionalized cyanuric acid moiety. The connecting chains are varied to include, for instance, oligo(ethylene glycol) or chains containing 1,2,3-triazole units to present flexibility in the chemical and structural space and potentially deliver functional molecules for molecular recognition applications.
我们描述了一种具有独特结构的基于胆酸盐的笼状两亲分子，它结合了结构刚性和灵活性的元素。笼状化合物是通过在胆酸盐的凹面甾体环下方延伸和桥接三条极性链，并与另一个刚性的、对称三官能化的氰尿酸部分封端而构建的。连接链有所不同，例如包括聚乙二醇或含有1,2,3 - 三唑单元的链，以在化学和结构空间中展现灵活性，并有可能为分子识别应用提供功能分子。
