Karimi Babak, Rajabi Jamshid
Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P.O. Box 45195-159, Gava Zang, Zanjan, Iran.
Org Lett. 2004 Aug 19;6(17):2841-4. doi: 10.1021/ol049294+.
In this work, a new method for highly efficient and selective oxidative deprotection of a variety of structurally diverse trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) ethers using molecular oxygen in the presence of N-hydroxyphthalimide (NHPI) and various types of Co(II) complexes is reported. As a result of the relatively neutral reaction medium, acid-sensitive functional groups such as phenolic TBS ethers survived intact under the presented reaction conditions.
在本工作中，报道了一种在N-羟基邻苯二甲酰亚胺（NHPI）和各种类型的Co（II）配合物存在下，使用分子氧对多种结构不同的三甲基硅基（TMS）和叔丁基二甲基硅基（TBS）醚进行高效、选择性氧化脱保护的新方法。由于反应介质相对中性，酸性敏感官能团如酚类TBS醚在所述反应条件下保持完整。
