Department of Chemistry, Sungkyunkwan University, Suwon, Gyeonggi 440-746, Korea.
Org Biomol Chem. 2011 Dec 7;9(23):8119-21. doi: 10.1039/c1ob06300f. Epub 2011 Oct 11.
A mild and efficient protocol for the deprotection of silyl ethers using KF in tetraethylene glycol is reported. A wide range of alcoholic silyl ethers can be selectively cleaved in high yield in the presence of certain acid- and base-labile functional groups. Moreover, the phenolic silyl ethers were cleaved exclusively, without affecting the alcoholic silyl ethers, at room temperature.
本文报道了一种使用 KF 在四乙二醇中脱保护硅醚的温和、高效的方法。在某些酸和碱不稳定官能团的存在下，多种醇基硅醚可以被选择性地以高产率裂解。此外，室温下，酚基硅醚可以被专一性地裂解，而不会影响醇基硅醚。
