Oberthür Markus, Leimkuhler Catherine, Kahne Daniel
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
Org Lett. 2004 Aug 19;6(17):2873-6. doi: 10.1021/ol049187f.
Beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from alpha-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.
β-2-脱氧糖核苷酸是多种糖基转移酶（Gtfs）使用的底物。我们已经开发出一种从α-糖基氯开始合成β-2-脱氧糖磷酸酯的化学路线。我们的方法可靠地提供了一系列对于研究参与生物活性天然产物合成的糖基转移酶至关重要的NDP-β-2-脱氧糖。
