一种立体选择性生成β-2-脱氧糖基磷酸酯的实用方法。
A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates.
作者信息
Oberthür Markus, Leimkuhler Catherine, Kahne Daniel
机构信息
Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
出版信息
Org Lett. 2004 Aug 19;6(17):2873-6. doi: 10.1021/ol049187f.
PMID:15330636
Abstract
Beta-2-Deoxy sugar nucleotides are substrates used by a variety of glycosyltransferases (Gtfs). We have developed a chemical route to synthesize beta-2-deoxy sugar phosphates that starts from alpha-glycosyl chlorides. Our approach reliably provides access to a range of NDP beta-2-deoxy sugars essential for studying glycosyltransferases involved in the synthesis of biologically active natural products.
摘要
β-2-脱氧糖核苷酸是多种糖基转移酶（Gtfs）使用的底物。我们已经开发出一种从α-糖基氯开始合成β-2-脱氧糖磷酸酯的化学路线。我们的方法可靠地提供了一系列对于研究参与生物活性天然产物合成的糖基转移酶至关重要的NDP-β-2-脱氧糖。
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