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用于检测恶性胆管狭窄的荧光原位杂交技术:荧光原位杂交技术找到新领域了吗?

Fluorescence in situ hybridization for the detection of malignant bile duct strictures: has FISH found a new pond?

作者信息

Wamsteker Erik-Jan, Anderson Michelle A

出版信息

Am J Gastroenterol. 2004 Sep;99(9):1682-3. doi: 10.1111/j.1572-0241.2004.40744.x.

DOI:10.1111/j.1572-0241.2004.40744.x
PMID:15330901
Abstract

Routine cytology for the diagnosis of biliary and pancreatic malignancies has exceptionally poor sensitivity and has spurred a search for new technology in the evaluation of these diseases. The recent study by Kipp et al. in this issue of the Journal, compares one of these novel techniques (fluorescence in situ hybridization to standard cytology) for the detection of malignant biliary strictures. Although larger studies are indicated, the modality shows considerable promise for future clinical use.

摘要

用于诊断胆管和胰腺恶性肿瘤的常规细胞学检查敏感性极低,这促使人们寻找评估这些疾病的新技术。Kipp等人在本期《杂志》上发表的最新研究,比较了其中一种新技术(荧光原位杂交与标准细胞学检查)在检测恶性胆管狭窄方面的效果。尽管还需要更大规模的研究,但这种方法在未来临床应用中显示出了巨大的潜力。

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引用本文的文献

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Diagnostic approaches for cholangiocarcinoma.胆管癌的诊断方法。
World J Gastroenterol. 2008 Jul 14;14(26):4131-6. doi: 10.3748/wjg.14.4131.
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Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma.肝门部胆管癌患者的内镜经乳头刷检细胞学检查和钳取活检
World J Gastroenterol. 2008 Feb 21;14(7):1097-101. doi: 10.3748/wjg.14.1097.