Coppola Angelo G, Karakousis Pietor C, Metz David C, Go Mae F, Mhokashi M, Howden Colin W, Raufman Jean-Pierre, Sharma Virender K
Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Am J Gastroenterol. 2004 Sep;99(9):1720-5. doi: 10.1111/j.1572-0241.2004.10370.x.
Increasingly, primary care (PC) physicians will be the first to encounter patients with hepatitis C virus (HCV) infection.
To determine opinions and practices of PC residents regarding HCV.
We administered a one-page questionnaire to 180 PC residents at five U.S. training programs.
Respondents were distributed equally across postgraduate year, 83% were U.S. graduates, and 44% had seen >11 (HCV) patients in the past year. Residents tested for HCV in persons with: increased transaminases (83%), history of blood transfusion (46%), multiple tattoos (57%), +ANCA (16%), and alcohol abuse (31%). Sixteen percent of respondents tested all patients. Forty-one percent would vaccinate HCV patients for hepatitis A and 65% for hepatitis B while only 19% and 78% knew the respective vaccination schedules. Although no vaccine is available, 66% recommended vaccination for HCV. Only 37% and 29%, respectively, reported HCV genotype 1 as most common and most resistant to treatment. Fifty-three percent recommend liver biopsy before treating HCV. Only 52% reported alpha-interferon (IFN) with ribavirin as initial treatment for HCV while 28% recommend ribavirin or lamivudine alone or combinations of IFN and lamivudine or amantadine. As contraindications to treatment, 33% reported AIDS with PCP infection, 19% coronary artery disease, and 19% suicidal ideation. Sixty-nine percent felt that there was insufficient information on HCV.
Many PC residents lack adequate knowledge of recommended guidelines for the management of HCV. Many test for HCV in inappropriate situations, are unclear regarding available vaccines and their administration, and are uncertain about current treatment. Education of PC residents on guidelines for detection and management of HCV must be improved.
基层医疗(PC)医生将越来越多地首先接诊丙型肝炎病毒(HCV)感染患者。
确定基层医疗住院医师对HCV的看法和做法。
我们向美国五个培训项目的180名基层医疗住院医师发放了一份单页问卷。
受访者在研究生年级中分布均匀,83%是美国毕业生,44%在过去一年中看过超过11名(HCV)患者。住院医师对以下人群进行HCV检测:转氨酶升高者(83%)、有输血史者(46%)、有多个纹身者(57%)、抗中性粒细胞胞浆抗体阳性者(16%)和酗酒者(31%)。16%的受访者对所有患者进行检测。41%的人会为HCV患者接种甲型肝炎疫苗,65%会接种乙型肝炎疫苗,而只有19%和78%的人分别知道各自的疫苗接种方案。虽然尚无可用疫苗,但66%的人建议为HCV患者接种疫苗。分别只有37%和29%的人报告HCV基因型1是最常见和最耐药的。53%的人建议在治疗HCV之前进行肝活检。只有52%的人报告将α干扰素(IFN)与利巴韦林作为HCV的初始治疗方案,而28%的人建议单独使用利巴韦林或拉米夫定,或IFN与拉米夫定或金刚烷胺的联合使用。作为治疗的禁忌证,33%的人报告为艾滋病合并肺孢子菌肺炎感染,19%为冠状动脉疾病,19%为自杀意念。69%的人认为关于HCV的信息不足。
许多基层医疗住院医师对HCV管理的推荐指南缺乏足够的了解。许多人在不适当的情况下进行HCV检测,对可用疫苗及其接种情况不清楚,并且对当前治疗方案不确定。必须加强对基层医疗住院医师关于HCV检测和管理指南的教育。