Wu Ling-Gang
National Institute of Neurological Disorders and Stroke, 36 Convent Drive, Building 36, Room 1C12, Bethesda, MD 20892, USA.
Trends Neurosci. 2004 Sep;27(9):548-54. doi: 10.1016/j.tins.2004.07.001.
Studies from a variety of synapses indicate that the time course of endocytosis ranges from less than a second to hundreds of seconds. This raises questions about how the time course of endocytosis is regulated and why different rates of endocytosis are needed. Recent progress sheds light on these issues. Neuronal firing frequency and duration determine the time course of endocytosis. The dynamic nature of this time course could be a result of multiple endocytic pathways and/or of regulation by a variety of modulators. Because endocytosis is crucial for maintaining transmitter release during repetitive stimulation, regulation of endocytosis could thus provide a mechanism by which synaptic plasticity is achieved.
来自各种突触的研究表明，内吞作用的时间进程从不到一秒到数百秒不等。这就引发了关于内吞作用的时间进程是如何被调节的以及为什么需要不同的内吞速率的问题。最近的进展为这些问题提供了线索。神经元的放电频率和持续时间决定了内吞作用的时间进程。这个时间进程的动态性质可能是多种内吞途径和/或多种调节剂调节的结果。由于内吞作用对于在重复刺激期间维持神经递质释放至关重要，因此内吞作用的调节可能提供了一种实现突触可塑性的机制。
