Samore M H, Siber G R
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, MA 02115.
J Infect Dis. 1992 May;165(5):945-8. doi: 10.1093/infdis/165.5.945.
Pertussis toxin is an important virulence factor of Bordetella pertussis that may also contribute to the toxicity of pertussis vaccines. The effect of low doses of pertussis toxin on response to Haemophilus influenzae type b (Hib) infection was examined in infant rats. Pretreatment of rats with 10 or 100 ng of pertussis toxin increased blood bacterial concentration (P less than .01), serum endotoxin levels (P less than .01), and mortality (P less than .05) relative to saline pretreated controls challenged with 4 x 10(3) Hib intraperitoneally. The 100-ng dose of pertussis toxin, but not the 10-ng dose, increased the leukocyte count. Thus, doses of pertussis toxin less than the threshold dose for inducing leukocytosis may enhance the susceptibility of infant rats to Hib infections.
百日咳毒素是百日咳博德特氏菌的一种重要毒力因子，它也可能导致百日咳疫苗的毒性。在幼鼠中研究了低剂量百日咳毒素对b型流感嗜血杆菌（Hib）感染反应的影响。相对于用4×10³ 个Hib腹腔注射攻击的生理盐水预处理对照组，用10或100纳克百日咳毒素预处理大鼠可增加血液细菌浓度（P<0.01）、血清内毒素水平（P<0.01）和死亡率（P<0.05）。100纳克剂量的百日咳毒素可增加白细胞计数，但10纳克剂量则无此作用。因此，低于诱导白细胞增多阈值剂量的百日咳毒素可能会增强幼鼠对Hib感染的易感性。
