Sawant Bilvadaa U, Nadkarni Ganeshsunder D, Thakare Usha R, Joseph Lebana J, Rajan M G R
Laboratory Nuclear Medicine Section, Isotope Group, (BARC), C/o Tata Memorial Centre Annexe, Parel, Mumbai 400 012, India.
Indian J Exp Biol. 2003 Nov;41(11):1334-7.
Kidney weight was significantly decreased in hypothyroidism (induced by Na131I administration) and increased in hyperthyroidism (induced by thyroxine treatment) as compared to control in female Wistar rats. The tissue lipid peroxidation level remained unchanged in hyperthyroid rats but significantly increased in hypothyroid rats. Superoxide dismutase was decreased in both experimental groups but more so in hyperthyroid rats. Catalase was reduced significantly in hyperthyroid rats but remained unaffected in hypothyroid rats. Tissue glutathione peroxidase (GPx) activity was increased while reduced glutathione levels remained unaltered in both hypothyroid and hyperthyroid rats. Plasma GPx activity was significantly low in both the hypothyroid and hyperthyroid rats. The results suggest alterations in the oxidative stress in hypothyroid and hyperthyroid rat kidneys with concomitant changes of free radical scavengers.
与雌性Wistar大鼠对照组相比，甲状腺功能减退（通过给予Na131I诱导）时肾脏重量显著降低，甲状腺功能亢进（通过甲状腺素治疗诱导）时肾脏重量增加。甲状腺功能亢进大鼠的组织脂质过氧化水平保持不变，但甲状腺功能减退大鼠的该水平显著升高。两个实验组的超氧化物歧化酶均减少，但甲状腺功能亢进大鼠减少得更多。甲状腺功能亢进大鼠的过氧化氢酶显著降低，但甲状腺功能减退大鼠的过氧化氢酶未受影响。甲状腺功能减退和甲状腺功能亢进大鼠的组织谷胱甘肽过氧化物酶（GPx）活性均增加，而还原型谷胱甘肽水平均未改变。甲状腺功能减退和甲状腺功能亢进大鼠的血浆GPx活性均显著降低。结果表明，甲状腺功能减退和甲状腺功能亢进大鼠肾脏的氧化应激发生改变，同时自由基清除剂也发生变化。
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