Department of Pediatric Medicine, Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal.
Department of Pediatric Medicine, National Academy of Medical Sciences, Mahaboudha, Kathmandu, Nepal.
JNMA J Nepal Med Assoc. 2024 Feb 24;62(270):110-113. doi: 10.31729/jnma.8455.
Nephrotic syndrome is a glomerular disease characterized by massive urinary protein loss occurring in children. Proteinuria also leads to loss of thyroid binding globulin affecting thyroid function. This study aimed to find out the prevalence of hypothyroidism among children with nephrotic syndrome admitted to a tertiary care centre.
A descriptive cross-sectional study was conducted among children with nephrotic syndrome admitted to a tertiary care centre from 06 July 2020 to 06 June 2021 after obtaining ethical approval from the Ethical Review Committee. They were tested for free T3, free T4 and TSH. A convenience sampling method was used. The point estimate was calculated at a 90% Confidence Interval.
Among 69 children with nephrotic syndrome, the prevalence of hypothyroidism was 49 (71.01%) (62.03-80.00, 90% Confidence Interval).
The prevalence of hypothyroidism among children with nephrotic syndrome was higher than other studies done in similar settings.
children; hypothyroidism; nephrotic syndrome; prevalence.
肾病综合征是一种肾小球疾病，其特征是大量蛋白尿出现在儿童中。蛋白尿还会导致甲状腺结合球蛋白丢失，从而影响甲状腺功能。本研究旨在探讨三级护理中心收治的肾病综合征患儿中甲状腺功能减退症的患病率。
本研究为描述性横断面研究，于 2020 年 7 月 6 日至 2021 年 6 月 6 日在获得伦理审查委员会的伦理批准后，在三级护理中心收治的肾病综合征患儿中进行。他们接受了游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素的检测。采用方便抽样法。点估计值在 90%置信区间内计算。
在 69 例肾病综合征患儿中，甲状腺功能减退症的患病率为 49 例（71.01%）（62.03%-80.00%，90%置信区间）。
肾病综合征患儿甲状腺功能减退症的患病率高于其他在类似环境中进行的研究。
儿童；甲状腺功能减退症；肾病综合征；患病率。
