Habibovic P, van der Valk C M, van Blitterswijk C A, De Groot K, Meijer G
Institute of Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10-D, 3723 MB, Bilthoven, The Netherlands.
J Mater Sci Mater Med. 2004 Apr;15(4):373-80. doi: 10.1023/b:jmsm.0000021104.42685.9f.
In this study, we investigated the influence of octacalcium phosphate (OCP) coating on osteoinductive behaviour of the biomaterials. Porous titanium alloy (Ti6Al4V), hydroxyapatite (HA), biphasic calcium phosphate (BCP) and polyethylene glyco terephtalate/polybuthylene terephtalate (PEGT-PBT) copolymer, all uncoated and coated with biomimetically produced OCP, were implanted in back muscles of 10 goats for 6 and 12 weeks. Uncoated Ti6Al4Vand HA did not show any bone formation after intramuscular implantation. All OCP coated implants, except PEGT-PBT, did induce bone in the soft tissue. The reason for the non-inductive behaviour of the copolymer is probably its softness, that makes it impossible to maintain its porous shape after implantation. Both uncoated and OCP coated BCP induced bone. However, the amount of animals in which the bone was induced was higher in the coated BCP implants in comparison to the uncoated ones. Osteoinductive potential of biomaterials is influenced by various material characteristics, such as chemical composition, crystallinity, macro- and microstructure. OCP coating has a positive effect on osteoinductivity of the biomaterials. The combination of the advantages of biomimetic coating method above traditional methods, and a good osteoinductivity of OCP coating that is produced by using this method, opens new possibilities for designing more advanced orthopaedic implants.
在本研究中，我们调查了磷酸八钙（OCP）涂层对生物材料骨诱导行为的影响。将多孔钛合金（Ti6Al4V）、羟基磷灰石（HA）、双相磷酸钙（BCP）以及聚乙二醇对苯二甲酸酯/聚丁二醇对苯二甲酸酯（PEGT-PBT）共聚物，所有未涂层的以及用仿生法制备的OCP涂层的材料，植入10只山羊的背部肌肉中6周和12周。未涂层的Ti6Al4V和HA肌肉内植入后未显示任何骨形成。除PEGT-PBT外，所有OCP涂层植入物均在软组织中诱导出骨。共聚物无诱导行为的原因可能是其柔软性，这使得它在植入后无法保持其多孔形状。未涂层和OCP涂层的BCP均诱导出骨。然而，与未涂层的BCP植入物相比，涂层BCP植入物中诱导出骨的动物数量更多。生物材料的骨诱导潜力受各种材料特性影响，如化学成分、结晶度、宏观和微观结构。OCP涂层对生物材料的骨诱导性有积极影响。仿生涂层方法相对于传统方法的优势，以及使用该方法制备的OCP涂层具有良好的骨诱导性，为设计更先进的骨科植入物开辟了新的可能性。
