Yamasaki H, Sakai H
Department of Dentistry and Oral Surgery, School of Medicine, Fukuoka University, Japan.
Biomaterials. 1992;13(5):308-12. doi: 10.1016/0142-9612(92)90054-r.
Soft tissue reactions to two materials of different microstructure made with porous and dense hydroxyapatite ceramic granules, were compared in this study. Each was implanted subcutaneously in the abdomen of 10 dogs. The implants were removed 1, 3 and 6 months after implantation, and examined by light microscopy. Heterotopic bone formation was only evident around porous hydroxyapatite ceramic granules in 6 of the 10 animals after 3 months, and in all cases after 6 months, but never around dense granules. These findings suggested that cellular differentiation and induction of osteogenesis may be influenced by the physical and chemical factors in the micromilieu provided by porous hydroxyapatite ceramic granules.
本研究比较了由多孔和致密羟基磷灰石陶瓷颗粒制成的两种具有不同微观结构的材料的软组织反应。将每种材料皮下植入10只狗的腹部。植入后1、3和6个月取出植入物，并通过光学显微镜检查。3个月后，10只动物中有6只在多孔羟基磷灰石陶瓷颗粒周围仅出现异位骨形成，6个月后在所有病例中均出现，但致密颗粒周围从未出现。这些发现表明，细胞分化和成骨诱导可能受多孔羟基磷灰石陶瓷颗粒提供的微环境中的物理和化学因素影响。
