Liu Baoyi, Ma Zhijie, Li Junlei, Xie Hui, Wei Xiaowei, Wang Benjie, Tian Simiao, Yang Jiahui, Yang Lei, Cheng Liangliang, Li Lu, Zhao Dewei
Orthopaedic of Department, Affiliated ZhongShan Hospital of Dalian University, Dalian, 116001, China.
Bioact Mater. 2021 Sep 16;10:269-280. doi: 10.1016/j.bioactmat.2021.09.009. eCollection 2022 Apr.
Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages. However, high elastic modulus can cause stress shielding and lead to bone embrittlement. This study used an electron beam melting method to prepare personalized porous Ti6Al4V (pTi) bone plates. Then, chemical vapor deposition (CVD) technology coats tantalum (Ta) metal on the pTi bone plates. The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone, and no stress shielding occurred. In vitro experiments showed that compared with pTi plates, Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold. To better evaluate the function of the Ta-coated bone plate, animal experiments were conducted using a coat tibia fracture model. Our results showed that the Ta-coated bone plate could effectively fix the fracture. Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation. Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone. Therefore, this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.
由于其高强度优势，金属板一直是临床骨折内固定的金标准。然而，高弹性模量会导致应力屏蔽并引发骨质脆化。本研究采用电子束熔炼法制备个性化多孔Ti6Al4V（pTi）骨板。然后，通过化学气相沉积（CVD）技术在pTi骨板上涂覆钽（Ta）金属。制备的多孔钽涂层骨板具有与皮质骨相似的弹性模量，且未出现应力屏蔽现象。体外实验表明，与pTi板相比，钽涂层显著增强了细胞在支架表面的附着和增殖。为了更好地评估钽涂层骨板的功能，使用兔胫骨骨折模型进行了动物实验。我们的结果表明，钽涂层骨板能够有效固定骨折。影像学和组织学分析均显示，钽涂层骨板在骨痂形成方面具有显著的间接结合。组织学结果表明，新骨在界面处生长并与宿主骨形成良好的骨整合。因此，本研究为具有改善骨整合和成骨功能的生物功能钽涂层骨板在骨科应用中提供了一种替代方案。
