盘状球酸A和B：从一种未描述的青霉菌中分离得到的新型癸内酯，该青霉菌从藻类多管藻中获得。

Dictyosphaeric acids A and B: new decalactones from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria versluyii.

作者信息

Bugni Tim S, Janso Jeffrey E, Williamson R Thomas, Feng Xidong, Bernan Valerie S, Greenstein Michael, Carter Guy T, Maiese William M, Ireland Chris M

机构信息

Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.

出版信息

J Nat Prod. 2004 Aug;67(8):1396-9. doi: 10.1021/np049973t.

DOI:10.1021/np049973t

PMID:15332862

Abstract

Fungal isolate F01V25 was obtained from the alga Dictyosphaeria versluyii collected near Dravuni, Fiji, in 2001 and represented a previously undescribed Penicillium sp. Fermentation of isolate F01V25 resulted in the production of two new polyketides, dictyosphaeric acids A and B, along with the known anthraquinone carviolin. The relative stereochemistry of dictyosphaeric acids A and B was determined using the J-based configuration analysis method in conjunction with ROE and NOE correlations.

摘要

真菌分离株F01V25于2001年从斐济德拉武尼附近采集的藻类多管藻中获得，代表了一种先前未描述的青霉属物种。对分离株F01V25进行发酵，产生了两种新的聚酮化合物——多管藻酸A和B，以及已知的蒽醌类化合物香芹酮。多管藻酸A和B的相对立体化学结构通过基于J的构型分析方法结合ROE和NOE相关进行了测定。