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海洋源真菌中的蒽醌类化合物及其类似物：化学与生物活性。

Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities.

机构信息

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran.

Medicinal Plant Breeding & Development Research Institute, University of Kurdistan, Sanandaj 66177-15175, Iran.

出版信息

Mar Drugs. 2022 Jul 25;20(8):474. doi: 10.3390/md20080474.

DOI:10.3390/md20080474
PMID:35892942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9394430/
Abstract

Anthraquinones are an interesting chemical class of polyketides since they not only exhibit a myriad of biological activities but also contribute to managing ecological roles. In this review article, we provide a current knowledge on the anthraquinoids reported from marine-derived fungi, isolated from various resources in both shallow waters such as mangrove plants and sediments of the mangrove habitat, coral reef, algae, sponges, and deep sea. This review also tentatively categorizes anthraquinone metabolites from the simplest to the most complicated scaffolds such as conjugated xanthone-anthraquinone derivatives and bianthraquinones, which have been isolated from marine-derived fungi especially from the genera , , , , , , , , and other fungal strains. The present review, covering a range from 2000 to 2021, was elaborated through a comprehensive literature search using the following databases: ACS publications, Elsevier, Taylor and Francis, Wiley Online Library, MDPI, Springer, and Thieme. Thereupon, we have summarized and categorized 296 anthraquinones and their derivatives, some of which showed a variety of biological properties such as enzyme inhibition, antibacterial, antifungal, antiviral, antitubercular (against ), cytotoxic, anti-inflammatory, antifouling, and antioxidant activities. In addition, proposed biogenetic pathways of some anthraquinone derivatives are also discussed.

摘要

蒽醌类化合物是一类很有意思的聚酮类化合物，因为它们不仅表现出多种生物活性，而且有助于管理生态角色。在这篇综述文章中，我们提供了海洋来源真菌中报道的蒽醌类化合物的最新知识，这些化合物是从各种资源中分离出来的，包括浅水区的红树林植物和红树林生境的沉积物、珊瑚礁、藻类、海绵和深海。本综述还对蒽醌类代谢物进行了分类，从最简单到最复杂的支架，如共轭酮-蒽醌衍生物和双蒽醌类化合物，这些化合物都是从海洋来源的真菌中分离出来的，特别是从 、 、 、 、 、 、 和其他真菌菌株中分离出来的。本综述涵盖了 2000 年至 2021 年的范围，通过使用以下数据库进行全面的文献检索来详细阐述：ACS 出版物、爱思唯尔、泰勒弗朗西斯、威利在线图书馆、MDPI、施普林格和蒂梅。在此基础上，我们总结并分类了 296 种蒽醌类化合物及其衍生物，其中一些表现出多种生物活性，如酶抑制、抗菌、抗真菌、抗病毒、抗结核（针对 ）、细胞毒性、抗炎、防污和抗氧化活性。此外，还讨论了一些蒽醌衍生物的生物合成途径。

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