盘状球酸三环核心的汇聚合成。

A convergent synthesis of the tricyclic core of the dictyosphaeric acids.

作者信息

Barfoot Christopher W, Burns Alan R, Edwards Michael G, Kenworthy Martin N, Ahmed Mahmood, Shanahan Stephen E, Taylor Richard J K

机构信息

Department of Chemistry, University of York, Heslington, York YO10 5DD, United Kingdom.

出版信息

Org Lett. 2008 Jan 17;10(2):353-6. doi: 10.1021/ol702887e. Epub 2007 Dec 21.

DOI:10.1021/ol702887e

PMID:18095699

Abstract

The first synthetic route to the tricyclic core of the dictyosphaeric acids has been established starting from readily available (S)-(-)-4-(tert-butyldimethylsilyloxy)cyclohexenone and involving 9 steps, including a ring-closing metathesis to produce a 13-membered macrolactone, and a doubly tethered intramolecular Michael addition.

摘要

从容易获得的(S)-(-)-4-(叔丁基二甲基硅氧基)环己烯酮出发，已经建立了通往盘状球酸三环核心的第一条合成路线，该路线包含9步反应，包括用于生成一个13元大环内酯的闭环复分解反应，以及一个双连接的分子内迈克尔加成反应。