前列腺素类似物与血-房水屏障完整性：一项使用flare细胞仪的研究

Prostaglandin analogs and blood-aqueous barrier integrity: a flare cell meter study.

作者信息

Cellini M, Caramazza R, Bonsanto D, Bernabini B, Campos E C

机构信息

University of Bologna, Department of Surgical Science 'A. Valsalva', Ophthalmology Service, Bologna, Italy.

出版信息

Ophthalmologica. 2004 Sep-Oct;218(5):312-7. doi: 10.1159/000079472.

DOI:10.1159/000079472

PMID:15334011

Abstract

PURPOSE

To study, with an objective method, inflammation of the anterior segment of the glaucomatous eye after treatment with latanoprost, travoprost and bimatoprost.

MATERIALS AND METHODS

Sixty patients with chronic open-angle glaucoma aged between 38 and 76 years (mean 64.0 +/- 12.2) were randomly assigned to latanoprost 0.005, travoprost 0.004 and bimatoprost 0.03%. The study period lasted 6 months. Intraocular pressure (IOP) was measured every 2 weeks. We studied the intraocular inflammation before and after 3 and 6 months of therapy with an instrument composed of a He-Ne laser beam system, a photomultiplier mounted on a slitlamp microscope and a computer. This flare meter allows objective determination of the flare and the number of cells in the aqueous of the anterior chamber.

RESULTS

At the baseline, IOP was 26.4 +/- 3.6 mm Hg. After 3 months of treatment, mean IOP in the latanoprost group was 17.9 +/- 0.3 mm Hg (p < 0.001) with a mean cellularity of 12.638 +/- 3.284 photons/ms (p < 0.001). The travoprost group had an IOP of 17.2 +/- 0.3 mm Hg (p < 0.001) with a cellularity of 9.719 +/- 1.927 photons/ms (0.001). Finally, IOP in the bimatoprost group was 17.6 +/- 0.5 mm Hg (p < 0.001) with a cellularity of 6.138 +/- 1.475 photons/ms (p < 0.032). After 6 months of treatment, IOP in the latanoprost group was 18.1 +/- 0.3 (p < 0.001), in the travoprost group 17.3 +/- 0.3 (p < 0.001) and in the bimatoprost group 17.7 +/- 0.5 mm Hg (p < 0.001), whereas cellularity was 11.838 +/- 3.218 (p < 0.001), 8.950 +/- 3.692 (p < 0.001) and 7.617 +/- 2.603 photons/ms (p < 0.001), respectively. After 3 months, the travoprost (p < 0.013) and the bimatoprost groups (p < 0.001) had less flare compared with the latanoprost group and this remained so even at 6 months. When we compared the travoprost group with the bimatoprost group, we found significantly less flare at 3 months in the bimatoprost group (p < 0.001) but not at 6 months (p < 0.246).

CONCLUSIONS

The flare meter analysis shows that the eyes treated with bimatoprost and travoprost have a less significantly broken blood-aqueous barrier and their anterior chamber is also significantly less inflamed.

摘要

目的

采用客观方法研究拉坦前列素、曲伏前列素和比马前列素治疗后青光眼眼前节的炎症情况。

材料与方法

60例年龄在38至76岁（平均64.0±12.2岁）的慢性开角型青光眼患者被随机分为使用0.005%拉坦前列素组、0.004%曲伏前列素组和0.03%比马前列素组。研究期持续6个月。每2周测量一次眼压（IOP）。我们使用由氦氖激光束系统、安装在裂隙灯显微镜上的光电倍增管和计算机组成的仪器，研究治疗3个月和6个月前后的眼内炎症。这种闪光光度计可客观测定前房房水中的闪光和细胞数量。

结果

基线时，眼压为26.4±3.6 mmHg。治疗3个月后，拉坦前列素组平均眼压为17.9±0.3 mmHg（p<0.001），平均细胞密度为12.638±3.284光子/毫秒（p<0.001）。曲伏前列素组眼压为17.2±0.3 mmHg（p<0.001），细胞密度为9.719±1.927光子/毫秒（p<0.001）。最后，比马前列素组眼压为17.6±0.5 mmHg（p<0.001），细胞密度为6.138±1.475光子/毫秒（p<0.032）。治疗6个月后，拉坦前列素组眼压为18.1±0.3（p<0.001），曲伏前列素组为17.3±0.3（p<0.001），比马前列素组为17.7±0.5 mmHg（p<0.001），而细胞密度分别为11.838±3.218（p<0.001）、8.950±3.692（p<0.001）和7.617±2.603光子/毫秒（p<0.001）。3个月后，曲伏前列素组（p<0.013）和比马前列素组（p<0.001）与拉坦前列素组相比闪光更少，且6个月时依然如此。当我们比较曲伏前列素组和比马前列素组时，发现比马前列素组在3个月时闪光明显更少（p<0.001），但6个月时并非如此（p<0.246）。