神经肽Y在对乙醇和滥用药物的神经生物学反应中的作用。
A role for neuropeptide Y in neurobiological responses to ethanol and drugs of abuse.
作者信息
Thiele Todd E, Sparta Dennis R, Hayes Dayna M, Fee Jon R
机构信息
Department of Psychology, University of North Carolina at Chapel Hill, Davie Hall, CB 3270, Chapel Hill, NC 27599-3270, USA.
出版信息
Neuropeptides. 2004 Aug;38(4):235-43. doi: 10.1016/j.npep.2004.04.005.
In recent years, evidence has emerged suggesting that neuropeptide Y (NPY) is involved with neurobiological responses to ethanol and other drugs of abuse. Here, we provide an overview of physiological, pharmacological, and genetic research showing that: (A) administration of ethanol, as well as ethanol withdrawal, alter central NPY expression, (B) NPY modulates ethanol consumption under certain conditions, and (C) NPY signaling modulates the sedative effects of several drugs, including ethanol, sodium pentobarbital, and ketamine. Evidence suggesting possible mechanism(s) by which NPY signaling modulates ethanol consumption are considered. It is suggested that NPY may influence ethanol consumption by regulating basal levels of anxiety, by modulating the sedative effects of ethanol, and/or by modulating ethanol's rewarding properties.
近年来，有证据表明神经肽Y（NPY）参与了对乙醇及其他滥用药物的神经生物学反应。在此，我们对生理学、药理学和遗传学研究进行综述，结果表明：（A）给予乙醇以及乙醇戒断会改变中枢NPY的表达；（B）在某些条件下，NPY调节乙醇的摄入量；（C）NPY信号传导调节包括乙醇、戊巴比妥钠和氯胺酮在内的几种药物的镇静作用。文中还探讨了NPY信号传导调节乙醇摄入量可能的机制。研究表明，NPY可能通过调节基础焦虑水平、调节乙醇的镇静作用和/或调节乙醇的奖赏特性来影响乙醇的摄入量。
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