Thorsell Annika
Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-1108, USA.
Ann N Y Acad Sci. 2008 Dec;1148:136-40. doi: 10.1196/annals.1410.083.
One of the most profound properties of central neuropeptide Y (NPY) is its anxiolytic, or anti-anxiety, effect. This has been demonstrated repeatedly in a number of animal models. In addition, stressors affect NPY expression in the central nervous system, with acute and repeated (chronic) stress having differential effects. Here, a brief summary of some work performed in our laboratory is presented that supports a role for NPY in regulation of stress responses and behaviors.
中枢神经肽Y（NPY）最显著的特性之一是其具有抗焦虑作用。这一点已在多种动物模型中得到反复证实。此外，应激源会影响中枢神经系统中NPY的表达，急性应激和反复（慢性）应激具有不同的作用。在此，我们简要总结了在我们实验室开展的一些研究工作，这些工作支持NPY在应激反应和行为调节中发挥作用。
