Mostoslavsky Raul, Alt Frederick W, Rajewsky Klaus
Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2004 Sep 3;118(5):539-44. doi: 10.1016/j.cell.2004.08.023.
B lymphocytes produce diverse antibody specificities by "randomly" assembling antibody genes from germline segments. Yet, though each B lymphocyte has multiple allelic loci for the different antibody chains, each clonally derived mature B lymphocyte expresses a single species of antibody with a unique specificity via a process termed allelic exclusion. Despite some progress, the precise mechanism of allelic exclusion remains an enigma.
B淋巴细胞通过从种系片段中“随机”组装抗体基因来产生多样的抗体特异性。然而，尽管每个B淋巴细胞对于不同的抗体链有多个等位基因座，但每个克隆衍生的成熟B淋巴细胞通过一个称为等位基因排斥的过程表达一种具有独特特异性的单一抗体。尽管取得了一些进展，但等位基因排斥的确切机制仍然是个谜。
