Usami Yoshihide, Hatsuno Chikage, Yamamoto Hiroe, Tanabe Manabu, Numata Atsushi
Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan.
Chem Pharm Bull (Tokyo). 2004 Sep;52(9):1130-3. doi: 10.1248/cpb.52.1130.
Synthesis of the epimer of pericosine B from (-)-quinic acid was achieved. This synthesis involves some regioselective and stereoselective processes. The desired product showed lower cytotoxic activity in comparison with natural pericosine B against the P388 leukemia cell line. The result implies that the stereocenter of C-6 in natural pericosine B plays an important role in this activity.
实现了从（-）-奎尼酸合成紫苏霉素B的差向异构体。该合成涉及一些区域选择性和立体选择性过程。与天然紫苏霉素B相比，所得产物对P388白血病细胞系的细胞毒性活性较低。该结果表明天然紫苏霉素B中C-6的立体中心在该活性中起重要作用。
