Kasamaki A, Furuya K, Kanamitsu M
J Toxicol Sci. 1978 May;3(2):137-46. doi: 10.2131/jts.3.137.
Antibody to clioquinol(5-chloro-7-iodo-8-hydroxyquinoline:CIHQ) was detected by passive hemagglutinating reaction in rabbits receiving a prolonged administration of Emaform which was once a commercial preparation of CIHQ. The antibody was shown to be in the immunoglobulin fractions by separation with a specific immunoadsorbent, and it had relatively broad antigenic specificity. The antibody was also demonstrated in sera from patients who suffered from Subacute Myelo-Optico-Neuropathy (SMON) and from normal healthy individuals. However, its titer and frequency of positive reactors in the former were higher than those in the latter, and the two groups could be differentiated each other in frequency distribution patterns of the antibody proprietors. From these results, we discussed on desirable application of sero-epidemiological study to assessment of effects of chemical pollutants on living systems.
通过被动血凝反应在长期服用曾作为氯碘喹啉（CIHQ）商品制剂的埃马福明的兔子体内检测到了抗氯碘喹啉（5-氯-7-碘-8-羟基喹啉：CIHQ）抗体。通过用特异性免疫吸附剂分离表明该抗体存在于免疫球蛋白组分中，并且具有相对较宽的抗原特异性。在患有亚急性脊髓视神经病变（SMON）的患者和正常健康个体的血清中也检测到了该抗体。然而，前者的抗体滴度和阳性反应者频率高于后者，并且两组在抗体所有者的频率分布模式上可以相互区分。根据这些结果，我们讨论了血清流行病学研究在评估化学污染物对生物系统影响方面的理想应用。
