Kawaguchi T, Kumabe T, Watanabe M, Tominaga T
Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Acta Neurochir (Wien). 2004 Sep;146(9):1033-8; discussion 1038. doi: 10.1007/s00701-004-0313-5. Epub 2004 Jun 28.
A 22-year-old man presented with a rare case of atypical teratoid/rhabdoid tumour (AT/RT). Magnetic resonance imaging showed a left cerebellar mass with leptomeningeal dissemination. Partial resection was performed. Histological examination revealed AT/RT. Postoperatively, whole neuraxis and local irradiation were performed. Three-drug chemotherapy with ifosfamide, cisplatin, and etoposide, and adjuvant intrathecal administration of methotrexate were repeated. Near complete response was achieved, and no tumour recurrence/progression has been noticed during the follow up of 24 months. Intensive radiochemotherapy can successfully control AT/RT, even with leptomeningeal dissemination.
一名22岁男性患者出现了罕见的非典型畸胎样/横纹肌样瘤（AT/RT）病例。磁共振成像显示左小脑肿块伴软脑膜播散。进行了部分切除术。组织学检查显示为AT/RT。术后进行了全神经轴和局部放疗。重复使用异环磷酰胺、顺铂和依托泊苷进行三药化疗，并辅助鞘内注射甲氨蝶呤。达到了近乎完全缓解，在24个月的随访期间未发现肿瘤复发/进展。即使存在软脑膜播散，强化放化疗也能成功控制AT/RT。
