司美格鲁肽对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的脑多巴胺能系统损伤的神经保护作用。

The neuroprotective effects of Semax in conditions of MPTP-induced lesions of the brain dopaminergic system.

作者信息

Levitskaya N G, Sebentsova E A, Andreeva L A, Alfeeva L Yu, Kamenskii A A, Myasoedov N F

机构信息

Institute of Molecular Genetics, Russian Academy of Sciences, 123182 Moscow, Russia.

出版信息

Neurosci Behav Physiol. 2004 May;34(4):399-405. doi: 10.1023/b:neab.0000018752.59465.28.

DOI:10.1023/b:neab.0000018752.59465.28

PMID:15341218

Abstract

This report describes studies cf the effects of the ACTH(4-10) analog Semax (MEHFPGP) on the behavior of white rats with lesions to the brain dopaminergic system induced by the neurotoxin MPTP. Neurotoxin was given as single i.p. doses of 25 mg/kg. Neurotoxin injections were shown to decrease movement activity and increase anxiety in the animals. Daily intranasal administration of Semax at a dose of 0.2 mg/kg decreased the severity of MPTP-induced behavioral disturbances. The protective activity of Semax in MPTP-induced lesions of the brain dopaminergic system may be associated with both its modulating effect on the dopaminergic system and the neurotrophic action of the peptide.

摘要

本报告描述了促肾上腺皮质激素（4-10）类似物Semax（MEHFPGP）对经神经毒素MPTP诱导脑多巴胺能系统损伤的白鼠行为的影响研究。神经毒素以25mg/kg的单次腹腔注射剂量给予。已证实神经毒素注射会降低动物的运动活性并增加焦虑。每日以0.2mg/kg的剂量经鼻给予Semax可减轻MPTP诱导的行为障碍的严重程度。Semax在MPTP诱导的脑多巴胺能系统损伤中的保护活性可能与其对多巴胺能系统的调节作用以及该肽的神经营养作用有关。