Vilenskiĭ D A, Levitskaia N G, Andreeva L A, Alfeeva L Iu, Kamenskiĭ A A, Miasoedov N F
Ross Fiziol Zh Im I M Sechenova. 2007 Jun;93(6):661-9.
Effects of chronic intranasal administration of ACTH(4-10) analog Semax (MEHFPGP) on exploratory activity, anxiety level, and depression-like behaviour were studied in white rats. The peptide was injected daily in dose 0.05 mg/kg during 10 or 14 days. It was shown that chronic Semax administration at 1-2 weeks induced anxiolytic and antidepressant effects but did not influenced the exploratory activity in non-stressogenic environment. The Semax effects may be the results of activation of the brain serotoninergic system as well as increased BDNF expression in the rat hippocampus.
