Effects of semax against the background of dopaminergic receptor blockade with haloperidol.
作者信息
Sebentsova E A, Levitskaya N G, Andreeva L A, Alfeeva L Yu, Kamenskii A A, Myasoedov N F
机构信息
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
出版信息
Bull Exp Biol Med. 2006 Feb;141(2):170-4. doi: 10.1007/s10517-006-0119-y.
We studied the neurotropic effects of ACTH(4-10) analog semax against the background of dopaminergic receptors blockade with haloperidol. Intranasal administration of semax (0.05, 0.2, and 0.6 mg/kg) produced virtually no effect on disturbances of orientation and exploratory reactions and motor activity caused by intraperitoneal injection of 0.2 mg/kg haloperidol. By contrast, preliminary administration of 0.05 mg/kg semax prevented haloperidol-induced disturbances in active avoidance conditioning.
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