Yopp Adam C, Krieger Nancy R, Ochando Jordi C, Bromberg Jonathan S
Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1104, New York, New York 10029-6574, USA.
Curr Opin Immunol. 2004 Oct;16(5):571-7. doi: 10.1016/j.coi.2004.07.003.
T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.
T细胞迁移和运输受明确的细胞过程调控，包括滚动、激活、紧密黏附、停滞和跨内皮迁移。反过来，这些过程又受涉及整合素、选择素、趋化因子和趋化因子受体的分子事件控制。最近的研究表明，1-磷酸鞘氨醇受体及其配体也是迁移和运输的重要分子调节因子。这些分子中的许多是预防同种异体移植排斥或实现免疫耐受的合适靶点。对迁移和运输的研究还表明，同种异体抗原呈递的解剖编排以及T细胞与同种异体抗原和免疫抑制的相遇，是T细胞启动与耐受的首要决定因素。
