Claas Frans
Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, PO Box 9600, 2300 RC, The Netherlands.
Curr Opin Immunol. 2004 Oct;16(5):578-83. doi: 10.1016/j.coi.2004.07.006.
The principle that the induction of (mixed) hematopoietic chimerism can lead to transplantation tolerance to another organ from the same donor has been verified in rodents, in large animals including non-human primates and recently in a selected group of renal transplant recipients. The wide application of this tool depends on the development of more gentle, non-toxic induction protocols and reliable assays with which to detect the establishment of stable donor-specific tolerance.
诱导（混合）造血嵌合体可导致对来自同一供体的另一个器官产生移植耐受这一原理，已在啮齿动物、包括非人灵长类动物在内的大型动物以及最近在一组选定的肾移植受者中得到验证。该工具的广泛应用取决于开发更温和、无毒的诱导方案以及用于检测稳定的供体特异性耐受建立的可靠检测方法。
