Larsen John Christian, Hunt Josephine, Perrin Irène, Ruckenbauer Peter
Institute of Food Safety and Nutrition, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.
Toxicol Lett. 2004 Oct 10;153(1):1-22. doi: 10.1016/j.toxlet.2004.04.020.
A number of mycotoxins of the class of trichothecenes are produced by a variety of Fusarium fungi commonly found on cereals. Unfavourable weather conditions may lead to a high level of Fusarium infections in crops such as wheat and correspondingly high trichothecene contents. The ILSI Europe Natural Toxin Task Force therefore organised a workshop on trichothecenes with a special focus on deoxynivalenol (DON). A number of experts reviewed the current knowledge on trichothecenes with respect to occurrence, including aspects of mould growth, toxin formation, storage and effects of processing; prevention; analytical methodologies, including sampling; surveillance and exposure assessments; and toxicology and risk assessment. A number of recommendations were given under the headings: prevention, sampling and analytical methods, exposure assessment, and toxicology. Gaps in knowledge were also identified.
多种单端孢霉烯族真菌毒素是由谷物上常见的多种镰刀菌产生的。不利的天气条件可能导致小麦等作物中镰刀菌感染程度很高,相应地单端孢霉烯族毒素含量也很高。因此,欧洲国际生命科学学会天然毒素特别工作组组织了一次关于单端孢霉烯族毒素的研讨会,特别关注脱氧雪腐镰刀菌烯醇(呕吐毒素)。一些专家审查了关于单端孢霉烯族毒素在发生方面的现有知识,包括霉菌生长、毒素形成、储存及加工影响等方面;预防措施;分析方法,包括采样;监测与暴露评估;以及毒理学和风险评估。在预防、采样与分析方法、暴露评估以及毒理学等标题下给出了一些建议。还确定了知识空白。