Xu X, Davis R E
Mental Health Research Institute, University of Michigan, Ann Arbor 48104-1687.
Behav Neurosci. 1992 Apr;106(2):307-14. doi: 10.1037//0735-7044.106.2.307.
The amnestic effects of the noncompetitive antagonist MK-801 on visually mediated, classic fear conditioning in goldfish (Carassius auratus) was examined in 5 experiments. MK-801 was administered 30 min before the training session on Day 1 to look for anterograde amnestic effects, immediately after training to look for retrograde amnestic effects, and before the training or test session, or both, to look for state-dependence effects. The results showed that MK-801 produced anterograde amnesia at doses that did not produce retrograde amnesia or state dependency and did not impair the expression of conditioned or unconditioned branchial suppression responses (BSRs) to the conditioned stimulus. The results indicate that MK-801 disrupts the mechanism of learning of the conditioned stimulus-unconditioned stimulus relation. Evidence is also presented that the learning processes that are disrupted by MK-801 occur during the initial stage of BSR conditioning.
在5项实验中，研究了非竞争性拮抗剂MK-801对金鱼（Carassius auratus）视觉介导的经典恐惧条件反射的遗忘效应。在第1天训练前30分钟给予MK-801以寻找顺行性遗忘效应，训练后立即给予以寻找逆行性遗忘效应，在训练或测试前或两者之前给予以寻找状态依赖性效应。结果表明，MK-801在不产生逆行性遗忘或状态依赖性且不损害对条件刺激的条件性或非条件性鳃抑制反应（BSR）表达的剂量下产生顺行性遗忘。结果表明，MK-801破坏了条件刺激-非条件刺激关系的学习机制。还提供了证据表明，被MK-801破坏的学习过程发生在BSR条件反射的初始阶段。
