Hoehn-Saric R, McLeod D R, Glowa J R
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD.
Biol Psychiatry. 1991 Jul 15;30(2):170-6. doi: 10.1016/0006-3223(91)90171-h.
Excitatory amino acids, acting at the N-methyl-d-aspartate (NMDA) receptor, have been postulated to play an important role in the acquisition of behavior (learning). Previous studies have shown that some forms of response acquisition can be impaired by drugs that block the NMDA receptor. To determine whether excitatory amino acid blockade could also affect the ability to acquire an emotional response, the effects of the noncompetitive NMDA receptor antagonist MK-801 were studied on the development of response suppression under a conditioned emotional response (CER) procedure in the rat. The CER procedure progressively suppressed responding when saline was given prior to the eight daily sessions over which animals were initially exposed. Daily treatment with MK-801 blocked the development of response suppression. Thus, these data are consistent with the notion that excitatory amino acid blockade prevents or diminishes the development of a learned emotional response. This suggests a potential role for this receptor in the development of anxiety-related disorders in humans.
作用于 N-甲基-D-天冬氨酸（NMDA）受体的兴奋性氨基酸被认为在行为习得（学习）中起重要作用。先前的研究表明，一些形式的反应习得会受到阻断 NMDA 受体的药物的损害。为了确定兴奋性氨基酸阻断是否也会影响获得情绪反应的能力，研究了非竞争性 NMDA 受体拮抗剂 MK-801 对大鼠在条件性情绪反应（CER）程序下反应抑制发展的影响。在最初让动物接触的八次每日实验之前给予生理盐水时，CER 程序会逐渐抑制反应。每日用 MK-801 治疗可阻断反应抑制的发展。因此，这些数据与兴奋性氨基酸阻断可预防或减少习得性情绪反应发展的观点一致。这表明该受体在人类焦虑相关障碍的发展中可能发挥作用。
