Lang P F, Tamussino K, Hönigl W, Ralph G
Department of Obstetrics and Gynecology, University of Graz, Austria.
Am J Obstet Gynecol. 1992 May;166(5):1378-81. doi: 10.1016/0002-9378(92)91608-d.
Sixty patients with unruptured tubal pregnancy were treated with local laparoscopic instillation of 50% glucose solution. This treatment was successful in 49 (98%) of 50 patients with an initial serum human chorionic gonadotropin level of less than or equal to 2500 mU/ml and in six (60%) of 10 with an initial level greater than 2500 mU/ml. No side effects were seen. The average hospital stay of patients who did not require a second intervention was 5.2 days (range 3 to 10). The average time between glucose instillation and the decline of serum human chorionic gonadotropin levels below the level of detectability was 21.3 (+/- 14.3) and 30.2 (+/- 10.9) days in patients with serum levels less than or equal to 2500 mIU/ml and greater than 2500 mIU/ml, respectively. Five patients (8%) underwent a second laparoscopy (n = 4) or laparotomy (n = 1) because of stable or increasing human chorionic gonadotropin levels and progressing clinical symptoms. We conclude that laparoscopic instillation of hyperosmolar glucose solution is safe, technically simple, and effective in the treatment of unruptured tubal pregnancies associated with a serum human chronic gonadotropin level less than or equal to 2500 mIU/ml.
60例未破裂输卵管妊娠患者接受了腹腔镜下局部注入50%葡萄糖溶液的治疗。50例初始血清人绒毛膜促性腺激素水平小于或等于2500 mU/ml的患者中，49例（98%）治疗成功；10例初始水平大于2500 mU/ml的患者中，6例（60%）治疗成功。未观察到副作用。无需二次干预的患者平均住院时间为5.2天（范围3至10天）。血清人绒毛膜促性腺激素水平小于或等于2500 mIU/ml和大于2500 mIU/ml的患者，从注入葡萄糖到血清人绒毛膜促性腺激素水平降至可检测水平以下的平均时间分别为21.3（±14.3）天和30.2（±10.9）天。5例（8%）患者因人绒毛膜促性腺激素水平稳定或升高且临床症状进展，接受了二次腹腔镜检查（n = 4）或剖腹手术（n = 1）。我们得出结论，腹腔镜下注入高渗葡萄糖溶液治疗血清人绒毛膜促性腺激素水平小于或等于2500 mIU/ml的未破裂输卵管妊娠是安全、技术简单且有效的。
