腹腔镜下高渗葡萄糖注入与血清人绒毛膜促性腺激素（hCG）≤2500 mIU/mL的输卵管妊娠期待治疗对比
Laparoscopic instillation of hyperosmolar glucose vs. expectant management of tubal pregnancies with serum hCG < or = 2500 mIU/mL.
作者信息
Lang P F, Mäkinen J I, Irjala K M, Rantala M, Hönigl W, Tamussino K, Haas J
机构信息
Department of Obstetrics and Gynecology, University of Graz, Austria.
出版信息
Acta Obstet Gynecol Scand. 1997 Sep;76(8):797-800. doi: 10.3109/00016349709024350.
OBJECTIVE
To compare expectant management with local instillation of 50% glucose solution for tubal pregnancies with a serum hCG level < or = 2500 mIU/mL.
DESIGN
Prospective, non-randomized, comparative clinical study.
SETTING
Two university departments.
PATIENTS
One hundred and twenty-eight patients with laparoscopically-confirmed tubal pregnancy and serum hCG < or = 2500 mIU/mL.
INTERVENTIONS
Eighty patients in Graz were treated with laparoscopic instillation of 50% glucose solution and 48 patients in Turku were followed expectantly.
MAIN OUTCOME MEASURES
Resolution of hCG excretion, need for further interventions.
RESULTS
Seventy-four of the 80 patients (92%) in the glucose group (32 of 33 with an initial hCG < or = 250 mIU/mL and 42 of 47 with hCG 251-2500 mIU/mL) and 36 of 48 (75%) patients in the expectant group (19 of 23 with an initial hCG < or = 250 mIU/mL and 17 of 25 with hCG 251-2500 mIU/mL) had resolution of the pregnancy with no further intervention (p=0.008, chi-square test, odds ratio 0.24).
CONCLUSIONS
Glucose instillation is superior to expectant management for patients with early tubal pregnancy.
目的
比较期待治疗与局部滴注50%葡萄糖溶液治疗血清人绒毛膜促性腺激素（hCG）水平≤2500 mIU/mL的输卵管妊娠的效果。
设计
前瞻性、非随机、对照临床研究。
地点
两个大学科室。
患者
128例经腹腔镜确诊为输卵管妊娠且血清hCG≤2500 mIU/mL的患者。
干预措施
格拉茨的80例患者接受腹腔镜下滴注50%葡萄糖溶液治疗，图尔库的48例患者接受期待治疗。
主要观察指标
hCG排泄消失情况，是否需要进一步干预。
结果
葡萄糖组80例患者中的74例（92%）（初始hCG≤250 mIU/mL的33例中有32例，hCG为251 - 2500 mIU/mL的47例中有42例）以及期待治疗组48例患者中的36例（75%）（初始hCG≤250 mIU/mL的23例中有19例，hCG为251 - 2500 mIU/mL的25例中有17例）妊娠自行消退，无需进一步干预（p = 0.008，卡方检验，优势比0.24）。
结论
对于早期输卵管妊娠患者，滴注葡萄糖优于期待治疗。
Zotero 插件