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用于寡核苷酸合成的带有反应性残基连接子的单体：II. 基于尿苷和胞嘧啶且在2'位含有带甲氧基草酰胺基团连接子的亚磷酰胺的合成

[Monomers for oligonucleotide synthesis with linkers carrying reactive residues: II. Synthesis of phosphoamidites based of uridine and cytosine and containing a linker with methoxyoxalamide groups in position 2'].

作者信息

Vasil'eva S V, Abramova T V, Ivanova T M, Shishkin G V

出版信息

Bioorg Khim. 2004 May-Jun;30(3):264-72. doi: 10.1023/b:rubi.0000030130.99454.ae.

DOI:10.1023/b:rubi.0000030130.99454.ae
PMID:15344656
Abstract

A convenient preparative synthesis of 2'-amino-2'-deoxyuridine was developed. Starting from 2'-amino-2'-deoxyuridine and 2'-amino-2'-deoxycytidine, monomers for the phosphoamidite oligonucleotide synthesis were obtained that carry a linker with methoxyoxalamide groups in position 2'. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 3; see also http://www.maik.ru.

摘要

开发了一种便捷的2'-氨基-2'-脱氧尿苷的制备合成方法。以2'-氨基-2'-脱氧尿苷和2'-氨基-2'-脱氧胞苷为起始原料，获得了用于磷酰胺寡核苷酸合成的单体，这些单体在2'位带有带有甲氧基草酰胺基团的连接基。该论文的英文版本：《俄罗斯生物有机化学杂志》，2004年，第30卷，第3期；另见http://www.maik.ru 。

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