Brown C H
School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh, UK.
J Neuroendocrinol. 2004 Sep;16(9):727-39. doi: 10.1111/j.1365-2826.2004.01227.x.
Many neurones in the central nervous system possess intrinsic pattern-generating properties, including vasopressin magnocellular neurosecretory cells. Synaptic input to vasopressin cells is not rhythmically patterned and yet these neurones fire action potentials in a 'phasic' activity pattern comprised of alternating periods of activity and silence that each last tens of seconds. This review describes the intrinsic and extrinsic mechanisms that generate phasic activity in vasopressin cells, highlighting recent work that has shown phasic activity to result from feedback modulation of synaptic inputs, and of intrinsic membrane properties, by peptides released from the dendrites of vasopressin cells.
中枢神经系统中的许多神经元都具有内在的模式生成特性，包括血管加压素大细胞神经分泌细胞。血管加压素细胞的突触输入没有节律性模式，但这些神经元以“相位性”活动模式发放动作电位，该模式由持续数十秒的活动期和静息期交替组成。这篇综述描述了在血管加压素细胞中产生相位性活动的内在和外在机制，重点介绍了最近的研究工作，这些研究表明相位性活动是由血管加压素细胞树突释放的肽对突触输入和内在膜特性的反馈调节所导致的。
