Brown Colin H, Bourque Charles W
Centre for Neuroendocrinology and Department of Physiology, School of Medical Sciences, University of Otago, PO Box 913, Dunedin, New Zealand.
Trends Neurosci. 2006 Feb;29(2):108-15. doi: 10.1016/j.tins.2005.11.005. Epub 2005 Dec 5.
Many neurons in the CNS, including hypothalamic vasopressin-expressing cells, display rhythmic activity patterning. These vasopressin neurons receive random synaptic input but fire action potentials in alternating periods of activity and silence that each lasts tens of seconds. Recent work demonstrates that vasopressin cell rhythmicity depends on feedback modulation of intrinsic membrane properties and synaptic inputs by peptides released from the dendrites of these neurons. Many other neurons across the CNS release neurotransmitters from their dendrites; therefore, vasopressin cells provide an insight into the potential mechanisms that support neuronal activity patterning across the CNS.
中枢神经系统中的许多神经元，包括表达下丘脑加压素的细胞，都表现出节律性活动模式。这些加压素神经元接受随机的突触输入，但在持续数十秒的活动期和静息期交替发放动作电位。最近的研究表明，加压素细胞的节律性取决于这些神经元树突释放的肽对内在膜特性和突触输入的反馈调节。中枢神经系统中的许多其他神经元也从其树突释放神经递质；因此，加压素细胞为支持中枢神经系统神经元活动模式的潜在机制提供了见解。
