Stocker Roland
Centre for Vascular Research, University of New South Wales and Department of Haematology, Prince of Wales Hospital, Sydney, Australia.
Antioxid Redox Signal. 2004 Oct;6(5):841-9. doi: 10.1089/ars.2004.6.841.
Biliverdin and bilirubin are reducing species and hence potential antioxidants formed by the action of heme oxygenase and biliverdin reductase. Indeed, there is increasing evidence for the suggestion that a beneficial role of the potentially toxic bilirubin may be to act as a powerful chain-breaking antioxidant in biological systems, and that bilirubin may contribute to the cellular and tissue protection seen with increased heme oxygenase. This article reviews the in vitro antioxidant activities of the two bile pigments with emphasis on the different physiological forms of bilirubin and types of oxidants, and discusses these properties in light of the presence and reactivity other nonproteinaceous antioxidants.
胆绿素和胆红素是具有还原性的物质，因此是由血红素加氧酶和胆绿素还原酶作用形成的潜在抗氧化剂。事实上，越来越多的证据表明，具有潜在毒性的胆红素可能具有有益作用，即作为生物系统中强大的断链抗氧化剂，并且胆红素可能有助于因血红素加氧酶增加而产生的细胞和组织保护作用。本文综述了这两种胆汁色素的体外抗氧化活性，重点关注胆红素的不同生理形式和氧化剂类型，并根据其他非蛋白质类抗氧化剂的存在和反应性讨论了这些特性。
