HLA - DP 谷氨酸69和肿瘤坏死因子α（TNF -α）2基因标记物在铍超敏反应易感性中的作用。

Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity.

作者信息

Rogliani P, Amicosante M, Berretta F, Dotti C, Bocchino M, O'Donnell K M, Saltini C

机构信息

Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Rome, Italy.

出版信息

Int J Immunopathol Pharmacol. 2004 May-Aug;17(2 Suppl):3-10. doi: 10.1177/03946320040170S202.

DOI:10.1177/03946320040170S202

PMID:15345185

Abstract

Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts, characterized by the accumulation of CD4+ T cells and macrophages in the lower respiratory tract. Beryllium presentation to CD4+ T cells from patients with berylliosis results in T cell activation and these Be-specific CD4+ T cells undergo clonal proliferation and Th1-type cytokine production such as interleukin-2, interferon-gamma and tumor necrosis factor-alpha. In exposed workers, genetic susceptibility to this granulomatous disorder is associated with major histocompatibility gene and the TNF-alpha gene. The HLA-DP glutamic 69 residue was shown to be the MHC genetic marker associated with disease susceptibility; furthermore the TNF-alpha TNFA-308*2 allele was found to be independently associated with HLA-DP Glu69 in the determination of berylliosis risk.

摘要

铍中毒是一种因吸入铍尘导致的肺部环境性慢性炎症疾病，其特征是下呼吸道中CD4 + T细胞和巨噬细胞的积聚。铍中毒患者的CD4 + T细胞接触铍后会导致T细胞活化，这些铍特异性CD4 + T细胞会发生克隆增殖并产生Th1型细胞因子，如白细胞介素-2、干扰素-γ和肿瘤坏死因子-α。在接触铍的工人中，对这种肉芽肿性疾病的遗传易感性与主要组织相容性基因和肿瘤坏死因子-α基因有关。HLA-DP谷氨酸69残基被证明是与疾病易感性相关的MHC遗传标记；此外，在确定铍中毒风险时，发现肿瘤坏死因子-α TNFA-308*2等位基因与HLA-DP Glu69独立相关。